Adverse effects resulting from the use of zolpidem hemitartrate: A literature review
DOI:
https://doi.org/10.33448/rsd-v13i10.46967Keywords:
Zolpidem, Adverse effects, Overdose.Abstract
Objective: To investigate and discuss the risks associated with the use of the drug in order to clarify the possible damage to health. Methods: Through an integrative review, using the guiding question “What are the main adverse effects and impacts of using zolpidem?”. The search was carried out in the main databases: Latin American and Caribbean Health Sciences Literature (LILACS), Medical Literature and Retrieval System onLine (MEDLINE/PubMed®), Periódicos CAPES and Scientific Electronic Library Online (Scielo). MESH (Medical Subject Headings) and DeCs (Health Sciences Descriptors) were used as descriptors in the search strategy. The search strategy followed the criteria of the Boolean operator “AND”, which combines terms. The terms used were zolpidem “AND” adverse effects AND overdose, during the month of September 2024. Results: Zolpidem is a drug of paramount importance for the treatment of cases of insomnia, and long-term medical therapy should be monitored to assess efficacy, the emergence of adverse effects and the onset or worsening of comorbid conditions. Conclusion: Strict prescription control and continuous evaluation of its impact on patients' physical and mental health are essential to avoid abuse and serious complications.
Downloads
References
Amari, D. T., Juday, T., Frech, F. H., Wang, W., Wu, Z., Atkins Jr, N., & Wickwire, E. M. (2022). Falls, healthcare resources and costs in older adults with insomnia treated with zolpidem, trazodone, or benzodiazepines. BMC geriatrics, 22(1), 484.
Arnts, H., Tewarie, P., van Erp, W., Schuurman, R., Boon, L. I., Pennartz, C. M., ... & van den Munckhof, P. (2024). Deep brain stimulation of the central thalamus restores arousal and motivation in a zolpidem-responsive patient with akinetic mutism after severe brain injury. Scientific reports, 14(1), 2950.
Barbosa Eyler, G. E., & Vidal Utria, J. (2023). Dependencia y abstinencia de zolpidem: Reporte de un caso de convulsiones generalizadas. Revista Colombiana de Psiquiatría, 52(3), 265–267. https://doi.org/10.1016/j.rcp.2021.06.007.
Castro, L. S., Otuyama, L. J., Fumo-dos-Santos, C., Tufik, S., & Poyares, D. (2019). Sublingual and oral zolpidem for insomnia disorder: a 3-month randomized trial. Brazilian Journal of Psychiatry, 42(2), 175-184.
Edinoff, A. N., Wu, N., Ghaffar, Y. T., Prejean, R., Gremillion, R., Cogburn, M., ... & Kaye, A. D. (2021). Zolpidem: efficacy and side effects for insomnia. Health psychology research, 9(1).
Ferenidou, F., Mourikis, I., Sotiropoulou, P., & Vaidakis, N. (2019). Zolpidem related persistent genital arousal disorder: An interesting case. Psychiatrike= Psychiatriki, 30(4), 339-344.
Grzegorzewska, A., Landowski, J., & Cubała, W. J. (2020). Clinical considerations of sleep related amnestic behaviours associated with zolpidem. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii, 36(1), 23-31.
Harbourt, K., Nevo, O. N., Zhang, R., Chan, V., & Croteau, D. (2020). Association of eszopiclone, zaleplon, or zolpidem with complex sleep behaviors resulting in serious injuries, including death. Pharmacoepidemiology and drug safety, 29(6), 684-691.
Husnain, A., Qadeer, A., Tanvir, K., & Nadeem, A. (2024). Zolpidem’s insidious potential of abuse: A word of caution. JPMA. The Journal of the Pakistan Medical Association, 74(8), 1562-1563.
Inoue, Y., Nishida, M., Kubota, N., Koebis, M., Taninaga, T., Muramoto, K., ... & Moline, M. (2023). Comparison of the treatment effectiveness between lemborexant and zolpidem tartrate extended-release for insomnia disorder subtypes defined based on polysomnographic findings. Journal of Clinical Sleep Medicine, 19(3), 519-528.
Joung, K. I. (2023). Gender differences in spontaneous adverse event reports associated with zolpidem in South Korea, 2015–2019. Frontiers in Pharmacology, 14, 1256245.
Lai, S. W., Lin, C. L., & Liao, K. F. (2019). Association between colorectal cancer and zolpidem use in a case-control study. Medicine, 98(48), e18127.
Lima, W. D., da Silva, M. D., de Souza Costa, E., Pinheiro, F. I., de Azevedo, E. P., Cobucci, R. N., ... & Guzen, F. P. (2024). Abusive use of Zolpidem as a Result of COVID-19 and Perspectives of Continuity of the Problem in the Post-Pandemic Period. Current Neuropharmacology, 22(10), 1578-1582.
Machado, FV, Louzada, LL, Cross, NE, Camargos, EF, Dang-Vu, TT, & Nóbrega, OT (2020). Mais de um quarto de século do comprimido para dormir mais prescrito: revisão sistemática do uso de zolpidem por idosos. Gerontologia Experimental , 136 , 110962.
Medeiros Fernandes, M., da Silva, M. D., Pinto, A. G. A., de Araújo Silva, E., de Souza Cruz, F. X., Henriques, R. P. D. S. A., & de Paiva Cavalcanti, J. R. L. (2024). O uso do Zolpidem e suas repercussões neuropsiquiátricas: um estudo de revisão. Cuadernos de Educación y Desarrollo, 16(2 Edição Especial).
MEDICINA S/A. (2021). Busca por ansiolíticos e antidepressivos cresce mais de 100% na pandemia. Revista. Disponível em https://medicinasa.com.br/busca-ansioliticos-antidepressivos/#. Acesso em 9 de setembro de 2024.
Mittal, N., Mittal, R., & Gupta, M. C. (2021). Zolpidem for insomnia: a double-edged sword. A systematic literature review on Zolpidem-induced complex sleep behaviors. Indian Journal of Psychological Medicine, 43(5), 373-381.
Moorthy, R. S., Swetha, G., Rondla, R., Hu, A., Vallakeerthi, N., & Reddy, P. M. (2024). Greener and whiter analytical method development and validation for determining the presence of zolpidem tartrate infused in apple juice using RP-HPLC via magnetic solid-phase extraction followed by LC-MS confirmatory analysis. RSC advances, 14(38), 28168-28181.
Oliveira Azevedo, B., dos Santos, E. F., Lima, G. S., Pujol, J. T., Antunes, A. A., & Jesus, L. O. P. (2022). Perfil farmacoterapêutico do Zolpidem. Revista Brasileira de Ciências Biomédicas, 3(1), E0642022-1.
Russo, A. D., Hodgman, M., & Calleo, V. (2021). Seizures secondary to zolpidem withdrawal. Clinical Toxicology, 59(2), 174-175.
Snyder, H. (2019). Literature review as a research methodology. Journal of Business Research, v.104, p.333-339. Após citar o autor no item de Metodologia, deve colocar o autor citado no item de Referências:
Schifano, F., Chiappini, S., Corkery, J. M., & Guirguis, A. (2019). An insight into Z-drug abuse and dependence: an examination of reports to the European medicines agency database of suspected adverse drug reactions. International Journal of Neuropsychopharmacology, 22(4), 270-277.
Tavares, G., Kelmann, G., Tustumi, F., Tundisi, C. N., Silveira, B. R. B., Barbosa, B. M. A. C., ... & Bernardo, W. M. (2021). Cognitive and balance dysfunctions due to the use of zolpidem in the elderly: a systematic review. Dementia & Neuropsychologia, 15(03), 396-404.
Westerlind, B., Östgren, C. J., Mölstad, S., Midlöv, P., & Hägg, S. (2019). Use of non-benzodiazepine hypnotics is associated with falls in nursing home residents: a longitudinal cohort study. Aging clinical and experimental research, 31, 1087-1095.
Westermeyer, J., & Carr, T. M. (2020). Zolpidem-associated consequences: an updated literature review with case reports. The Journal of Nervous and Mental Disease, 208(1), 28-32.
Yu, Z., Han, L., Yan, P., Liu, W., Ren, L., Xu, Y., ... & Wang, S. (2024). Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder. Sleep and Breathing, 28(2), 929-934.
Zhang, H., Rong, H., Xiong, S., Chen, X., & Lin, Z. (2024). Intervention effect of electroacupuncture therapy on drug reducing and discontinuation of insomnia patients with long-term excessive use of zolpidem. Explore, 20(3), 328-333.
Zhou, M., & Tang, J. (2023). Effects of new hypnotic drugs on cognition: A systematic review and network meta-analysis. Sleep Medicine: X, 100094.
Zhou, M., Tang, J., Li, S., Li, Y., & Zhao, M. (2023). Orexin dual receptor antagonists, zolpidem, zopiclone, eszopiclone, and cognitive research: A comprehensive dose-response meta-analysis. Frontiers in Human Neuroscience, 16, 1029554.
Zhong, Z. G., Tao, G. J., Hao, S. M., Ben, H., Qu, W. M., Sun, F. Y., ... & Qiu, M. H. (2024). Alleviating sleep disturbances and modulating neuronal activity after ischemia: Evidence for the benefits of zolpidem in stroke recovery. CNS Neuroscience & Therapeutics, 30(2), e14637.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Altair Meirelles de Sousa Maia; Alex Felipe Mesquita Andrade ; Tainan Fabbri Scalco; Fernanda Júlia de Barros; Yasmin Quirino Queiroz; Willian Arthur Fidelis dos Santos; Dioelen Virginia Borges Souza de Aquino Coelho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
