Lasertherapy for the control of gustative and/or olfactory disorders resulting from infection by the SARS-CoV-2 virus: Pilot study
DOI:
https://doi.org/10.33448/rsd-v13i10.47001Keywords:
COVID-19, Photobiomodulation, Olfaction disorders, Taste disorders.Abstract
Introduction: Olfactory and gustatory dysfunctions resulting from the inflammatory process caused by SARS-CoV-2 have been frequently reported by patients. In view of this, photobiomodulation, a non-invasive method capable of providing biostimulatory, anti-inflammatory and regenerative effects, has been presented as a coherent approach to be used in the control of COVID-19 symptoms. Aim: To evaluate the effectiveness of the application of different therapeutic protocols of photobiomodulation in olfactory and gustatory dysfunctions resulting from infection by the SARS-CoV-2 virus. Methodology: Pilot Study of a Randomized Clinical Trial. Sample consisting of people who had COVID-19 and who still complained of partial and/or total olfactory and/or gustatory dysfunction three months after infection with SARS-CoV-2. Clinical and demographic data were collected from the clinical examination form, different photobiomodulation protocols were applied and the participants were evaluated for improvement or worsening of alterations with the performance of gustatory and olfactory tests. All information collected in the study was typed and conducted using the IBM SPSS Statistics computer program, version 29.0. Results: Participants showed improvement in olfactory and gustatory sensory perceptions in relation to the first tests performed at the beginning of the study, in all subgroups, and moved on to the follow-up phase for a period of 3, 6, 9 and 12 months. Conclusion: Laser therapy is a promising therapeutic method in the treatment of gustatory and olfactory disorders resulting from SARS-CoV-2 infection.
References
Bagnato, V. S. et al. (2021). Fotobiomodulação e terapias combinadas: protocolos de tratamento para as sequelas da COVID-19. https://mmo.com.br/wpfd_file/cepof_-fotobiomodulacao-e-terapias-combinadas-protocolos-de-tratamento-para-as-sequelas-da-covid-19/
Beltrán-Corbellini, Á., Chico-García, J. L., Martínez-Poles, J., Rodríguez-Jorge, F., Natera-Villalba, E., Gómez-Corral, J., Gómez-López, A., Monreal, E., Parra-Díaz, P., Cortés-Cuevas, J. L., Galán, J. C., Fragola-Arnau, C., Porta-Etessam, J., Masjuan, J., & Alonso-Cánovas, A. (2020). Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study. European journal of neurology, 27(9), 1738–1741. https://doi.org/10.1111/ene.14273
Campos, L., Soares, L. E. S., Berlingieri, G., Ramires, M. C. C. H., Guirado, M. M. G., Lyra, L. A. O. P., Teixeira, I. S., Oliveira, P. C., Alvares, C. M. A., & Palma, L. F. (2022). A Brazilian multicenter pilot case series on the efficacy of photobiomodulation therapy for COVID-19-related taste dysfunction. Photodiagnosis and photodynamic therapy, 37, 102643. https://doi.org/10.1016/j.pdpdt.2021.102643
Cumin, A. E.& Pereira, B. A. (2021). Anosmia e disgeusia associados a Covid-19. Trabalho de Conclusão de Curso. (Graduação em Odontologia) – Centro Universitário de Maringá, Paraná.
Favero, R., Hajrulla, S., Bordin, A., Mucignat-Caretta, C., Gaudioso, P., Scarpa, B., Favero, L., & Ottaviano, G. (2022). Olfactory Dysfunction in COVID-19 Patients Who Do Not Report Olfactory Symptoms: A Pilot Study with Some Suggestions for Dentists. International journal of environmental research and public health, 19(3), 1036. https://doi.org/10.3390/ijerph19031036
Ghods, K., & Alaee, A. (2022). Olfactory and Taste Disorders in Patients Suffering from Covid-19, a Review of Literature. Journal of dentistry (Shiraz, Iran), 23(1), 1–6. https://doi.org/10.30476/DENTJODS.2021.87800.1284
Juvekar, M., & Sarkar, B. (2021). Olfactory and Taste Dysfunction in Coronavirus Disease 2019 Pandemic. Indian journal of otolaryngology and head and neck surgery: official publication of the Association of Otolaryngologists of India, 74(Suppl 2), 3159–3166. https://doi.org/10.1007/s12070-021-02871-8
Kanjanaumporn, J., Aeumjaturapat, S., Snidvongs, K., Seresirikachorn, K., & Chusakul, S. (2020). Smell and taste dysfunction in patients with SARS-CoV-2 infection: A review of epidemiology, pathogenesis, prognosis, and treatment options. Asian Pacific journal of allergy and immunology, 38(2), 69–77. https://doi.org/10.12932/AP-030520-0826
Lechien, J. R., Chiesa-Estomba, C. M., De Siati, D. R., Horoi, M., Le Bon, S. D., Rodriguez, A., Dequanter, D., Blecic, S., El Afia, F., Distinguin, L., Chekkoury-Idrissi, Y., Hans, S., Delgado, I. L., Calvo-Henriquez, C., Lavigne, P., Falanga, C., Barillari, M. R., Cammaroto, G., Khalife, M., Leich, P., … Saussez, S. (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European archives of otorhinolaryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 277(8), 2251–2261. https://doi.org/10.1007/s00405-020-05965-1
Mastrangelo, A., Bonato, M., & Cinque, P. (2021). Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes. Neuroscience letters, 748, 135694. https://doi.org/10.1016/j.neulet.2021.135694
Nejatifard, M., Asefi, S., Jamali, R., Hamblin, M. R., & Fekrazad, R. (2021). Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review. Cytokine, 137, 155312. https://doi.org/10.1016/j.cyto.2020.155312
Palheta Neto, F. X., Targino, M. N., Peixoto, V. S., Alcântara, F. B., Jesus, C. C. D., Araújo, D. C. D., & Marçal Filho, E. F. D. L. (2011). Anormalidades sensoriais: olfato e paladar. Arquivos Internacionais de Otorrinolaringologia, 15, 350-358. https://doi.org/10.1590/S1809-48722011000300014
Parker, J. K., Kelly, C. E., & Gane, S. B. (2022). Insights into the molecular triggers of parosmia based on gas chromatography olfactometry. Communications medicine, 2, 58. https://doi.org/10.1038/s43856-022-00112-9
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica.[e-book]. Santa Maria. Ed. UAB/NTE/UFSM. Disponível em: https://repositorio. ufsm. br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica. pdf.
Santos, D. C. P., Vasconcelos, M. A. C., Moreira, P. H. de A., Gomes, P. D. B., Bazán, T. A. X. N., Moraes, F. P., Sousa, D. F., Siqueira, F. S. F. de, Silva, L. C. N. da, Holanda, R. A., & Galvão, L. C. de C. (2022). Sensory taste receptors and ageusia associated with SARS-CoV-2 infection: literature review. Research, Society and Development, 11(8), e32811829122. https://doi.org/10.33448/rsd-v11i8.29122.
Santos, I. H. A., Andrade, T. R. S. F., Torres, E. C., Freitas, A. P. de O., Jesus, C. V. F. de, & Ferrari, Y. A. C. (2020). Olfactory and gustatory dysfunctions in COVID-19. Research, Society and Development, 9(12), e42591211363. https://doi.org/10.33448/rsd-v9i12.11363
Silva, F. T. D., Sperandio, M., Suzuki, S. S., Silva, H. P. V., de Oliveira, D. G., Stefenon, L., & Garcez, A. S. (2022). Self-reported taste and smell impairment among patients diagnosed with COVID-19 in Brazil. Oral diseases, 28 Suppl 2, 2559–2562. https://doi.org/10.1111/odi.13951
Soares, L. E. S., Guirado, M. M. G., Berlingieri, G., Ramires, M. C. C. H., Lyra, L. A. O. P., Teixeira, I. S., Oliveira, P. C., Tateno, R. Y., Palma, L. F., & Campos, L. (2021). Intranasal photobiomodulation therapy for COVID-19-related olfactory dysfunction: A Brazilian multicenter case series. Photodiagnosis and photodynamic therapy, 36, 102574. https://doi.org/10.1016/j.pdpdt.2021.102574
Solmaz, H., Ulgen, Y., & Gulsoy, M. (2017). Photobiomodulation of wound healing via visible and infrared laser irradiation. Lasers in medical science, 32(4), 903–910. https://doi.org/10.1007/s10103-017-2191-0
Speth, M. M., Speth, U. S., Sedaghat, A. R., & Hummel, T. (2022). Riech- und Schmeckstörungen [Olfactory and gustatory disorders]. DGNeurologie, 5(3), 225–235. https://doi.org/10.1007/s42451-022-00434-x
Tan, H. Q. M., Pendolino, A. L., Andrews, P. J., & Choi, D. (2022). Prevalence of olfactory dysfunction and quality of life in hospitalised patients 1 year after SARS-CoV-2 infection: a cohort study. BMJ open, 12(1), e054598. https://doi.org/10.1136/bmjopen-2021-054598
Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T. (2020). The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(1), 3–11. https://doi.org/10.1177/0194599820926473
Vaira, L. A., Salzano, G., Fois, A. G., Piombino, P., & De Riu, G. (2020). Potential pathogenesis of ageusia and anosmia in COVID-19 patients. International forum of allergy & rhinology, 10(9), 1103–1104. https://doi.org/10.1002/alr.22593
Vidal, A. K. L. (2009). Protocolo Operacional Padrão de Cuidados Buco-Dentais (POP-Oral) para indivíduos sob terapia antineoplásica. Adaptado das Rotinas Internas do INCA (serviço de Odontologia). Nota prévia (Original), 2012.
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Copyright (c) 2024 Ângela Nathalie Silva Lima; Nathalia Matias de Freitas; Gabriele Gonçalves de Lima; William José e Silva Filho; Márcia de Melo Rodrigues; Cícero Eustáquio Rodrigues de Carvalho; Mônica Moreira Dias da Cruz; Aurora Karla de Lacerda Vidal
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