Rhodium (Rh): Metallic complexes applied against cancer
DOI:
https://doi.org/10.33448/rsd-v14i4.48600Keywords:
Cancer, Coordination chemistry, Chemotherapy, Rhodium (Rh).Abstract
This article consists of a review study focused on rhodium (Rh) metal complexes, covering the different possible oxidation states (rhodium(0), rhodium(I), rhodium(II) and rhodium(III)), aiming at a probable application of such coordination compounds in the fight against cancer. Rhodium (Rh) is an element of the platinum (Pt) group and one of the natural candidates for replacing the platinum coordination center in metal complexes that act biologically in a similar way to cisplatin and its analogues and successors. Therefore, the objective of this article is to discuss, through a bibliographic review, the aspects of the coordination chemistry of rhodium (Rh) and its mechanism of action in biological media aiming at its use against different manifestations of cancer, as a possible replacement for the so-called “classical” platinum (Pt) complexes, which are applied against cancer cells of different biological tissues. Finally, future perspectives for the applications of rhodium (Rh) complexes in chemotherapy are presented, as an “anticancer agent”, either alone or as a coadjuvant compound of platinum complexes.
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Almodares, Z., Lucas, S. J., Crossley, B. D., Basri, A. M., Pask, C. M., Hebden, A. J., Phillips, R. M., & McGowan, P. C. (2014). Rhodium, Iridium and Ruthenium Half-Sandwich Picolinamide Complexes as Anti-Cancer Agents. Inorganic, 53(2), 727-36.
Bailis, J. M., Weidmann, A. G., Marianno, N. F., & Barton, J. K. (2017). Rodhium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells. Proceedings of the National Academy of Sciences, 114(27), 6948-53.
Carneiro, M. L. B., Nunes, E. S., Peixoto, R. C. A., Oliveira, R. G. S., Lourenço, L. H. M., Silva, I. C. R., Simioni, A. R., Tedesco, A. C., Souza, A. R., Lacava, Z. G. M., & Báo, S. N. (2011). Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy. Journal of Nanobiotechnology, 9, 11 (17p).
Giraldi, T., Sava, G., Bertoli, G., Mestroni, G., & Zassinovich, G. (1977). Antitumor Action of Two Rhodium and Ruthenium Complexes in Comparison with cis-Diamminedichloroplatinum(II). Cancer Research, 37, 2662-66.
Graf, M., Ochs, J., Mayer, P., Metzler-Nolte, N., & Böttcher. (2023). Citotoxic Activity of Some Half-sandwich Rhodium(III) Complexes Containing 4,4´-disubstituted-2,2´-bipyridine Ligands. Journal of Inorganic and General Chemistry, 649, e202300195 (5p).
Gu, Y., Yang, K., Yang, Q., Li, H., Hu, M., Ma, M., Chen, N., Liu, Y., Liang, H., & Chen, Z. (2023). Rhodium(III)-Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy. Journal of Medicinal Chemistry, 66(14), 9592-06.
Islam, M. J., Kumer, A., & Khan, M. W. (2021). The theoretical study of anticancer rhodium complexes and methyl groups effect on ligands in chemical reactivity, global descriptors, ADMET by DFT study. Turkish Computational and Theoretical Chemistry, 5(2), 1-13.
Ivanova, S., Balkanski, S., Atanasov, P., Chaneva, M., Obreshkova, D., Dimitrov, V., Kazalukova, K., Peikova, L, & Markov, O. (2023). Antitumor and antioxidante activity of some metal complex compounds. Pharmacia, 70(2), 375-82.
Kacsir, I., Sipos, A., Kiss, T., Major, E., Bajusz, N., Tóth, E., Buglyó, P., Somsák, L., Kardos, G., Bai, P., & Bokor, E. (2023). Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria. Frontiers in Chemistry, 11, 1086267.
Katsaros, N., & Anagnostopoulou, A. (2002). Rhodium and its compounds as potential agents in cancer treatment. Critical Reviews in Oncology/Hematology, 42(3), 297-08.
Khan, T., Gul, N. S., Lu, X., Kumar, R., Choudary, M. I., Liang, H., & Chen, Z. (2019). Rhodium(III) complexes with isoquinoline derivatives as potential anticancer agents: in vitro and in vivo activity studies. Dalton Transactions, 30.
Kopacz-Bednarska, A., & Król, T. (2022). Selected platinum complexes in standard and modern anti-cancer therapies. Journal of Oncology, 72(2), 96-05.
Lee, J. D. (2003). Química Inorgânica não tão Concisa[trad. Henrique E. Toma; Koiti Araki, Reginaldo C. Rocha]. Editora Edgar Blücher Ltda., São Paulo-SP, 1a ed. (3a reimp. Da 5a ed. Inglesa).
Li, X., Wang, Y., Li, M., Wang, H., & Dong, X. (2022). Metal complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment. Molecules, 27, 148 (15p).
Lu, L., Liu, L., Chao, W., Zhong, H., Wang, M., Chen, X., Lu, J., Li, R., Ma, D., & Leung, C. (2015). Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity. Nature – Scientific Reports, 5, 14544 (9p).
Malikova, K., Masaryk, L., & Starha, P. (2021). Anticancer Half-Sandwich Rhodium(III) Complexes. Inorganics, 9, 26 (24p).
Matakabbir Hossain, M., Soha, K., Rahman, A., Auwal, A., T. U. Haque Pronoy, Rashel, K. M., Nurujjaman, M., Rahman, H., Roy, T. G., Khanam, J. A., & Islam, F. (2024). Rhodium complex [RhLI2]I: a novel anticâncer agente inducing tumor inhibition and apoptosis. Discover Oncology, 15, 782.
Moreira, L. M., & Lyon, J. P. (2025). Platina (Pt): Complexos metálicos e suas aplicações contra o câncer. Research, Society and Development, 14(3), e-4514348475 (9p).
Moreira, L. M., & Lyon, J. P. (2025). Rutênio (Ru): Propriedades, compostos de coordenação e aplicações catalíticas e farmacológicas. Research, Society and Development, 14(1), e6114148046.
Moreira, L. M., & Lyon, J. P. (2025). Paládio (Pd): propriedades, química de coordenação e aplicações contra o câncer. Research, Society and Development, 14(3), e7914348533 (9p).
Moreira, L. M., Lyon, J. P., Pereira, C., Silva, R. S., & Schultz, M. S. (2024). Manganês (Mn): Propriedades redox, química de coordenação e implicações biológicas. Research, Society and Development, 13(2), (2024) e13713245186.
Moreira, L. M., Lyon, J. P., & Teixeira, A. O. (2023). A relação estrutura-atividade da Vitamina B12 e das cobalaminas e suas correlações nutricionais. Research, Society and Development, 12(11), e05121143658.
Moreira, L. M., Teixeira, A. O., & Lyon, J. P. (2024). Cobre (Cu): Reatividade, compostos de coordenação e atuação biológica. Research, Society and Development, 13(3), e5313345291.
Moreira, L. M., Teixeira, A. O., & Lyon, J. P. (2023). A flexibilidade dos anéis macrocíclicos e as diferentes conformações espaciais de macrocíclicos metalados e não-metalados. Research, Society and Development, 12(10), e28121043407.
Moreira, L. M., Teixeira, A. O., & Lyon, J. P. (2022). Métodos Fototerapêuticos de relevância clínica. Research, Society and Development, 11(5), e51411528589.
Nano, A., Dai, J., Bailis, J. M., & Barton, J. K. (2021). Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair. Biochemistry, 60(26), 2055-63.
Ndagi, U., Mhlongo, N., & Soliman, M. E. (2017). Metal complexes in cancer therapy – an update from drug design perspective. Drug Design, Development and Therapy, 11, 599-16.
Peng, Y., He, W., Niu, Q., Tao, C., Zhong, X., Tan, C., & Zhao, P. (2021). Mitochondria-targeted cyclometalated rhodium(III) complexes: synthesis, characterization and anticancer research. Dalton Transactions, 26.
Peng, Y., Tao, C., Tan, C., & Zhao, P. (2021). Mitochondrial targeted rhodium(III) complexes: Synthesis, characterized and antitumor mechanism investigation. Journal of Inorganic Biochemistry, 218, 111400.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica [free e-book/repositório.ufsm.br]. Ed. UFSM. https://www.ufsm.br/app/uploads/sites/358/2019/02/Metodologia-da-Pesquisa-Científica_final.pdf
Rother, E. T. (2007). Revisão Sistemática X Revisão Narrativa. Acta Paulista de Enfermagem, 20(2), https://doi.org/10.1590/S0103-21002007000200001.
Sohrabi, M., Saeedi, M., Larijani, B., & Mahdavi, M. (2021). Recent advances in biological activities of rhodium complexes: Their applications in drug discovery research. European Journal of Medicinal Chemistry, 216, 113308 (9p).
Shriver, D. F., Atkins, P. W., Overton, T. L., Rourke, J. P., Weller, M. T., & Armstrong, F. A. (2008). Química Inorgânica [Trad. Roberto B. Farias; Cristina M. P. dos Santos] 4aed. Artmed Editora S. A., Porto Alegre-RS.
Trudu, F., Amato, F., Vanhara, P., Pivetta, T., Peña-Méndez, E. M., & Havel, J. (2015). Coordination compounds in cancer: Past, presente and perspectives. Journal of Applied Biomedicine, 13, 79-03.
Zhang, W., Bridgewater, H. E., Banerjee, S., Soldevila-Barreda, J. J., Clarkson, G. J., Shi, H., Imberti, C., & Sadler, P. J. (2020). Ligand-Controlled Reactivity and Cytotoxicity of Cyclometalated Rhodium(III) Complexes. European Journal of Inorganic Chemistry, 1052-60.
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