The effectiveness of active oxygen gel associated with conventional periodontitis treatment: An integrative review
DOI:
https://doi.org/10.33448/rsd-v14i5.48889Keywords:
Oxygen therapy, Periodontitis, Treatment.Abstract
This study aimed to evaluate the effectiveness of oral active oxygen gel, a topical oxygen-releasing agent, as an adjunctive treatment to conventional mechanical therapy in the management of periodontitis, focusing on the reduction of clinical inflammatory signs and the improvement of periodontal health. An integrative literature review was conducted using the PICO strategy to define the search criteria. The target population included patients with periodontitis; the intervention was the use of gel with active oxygen, compared to conventional treatment with scaling and root planing (SRP); and the outcome was the reduction of periodontal inflammation. The research was carried out in the PubMed database, selecting studies published between 2020 and 2025, following specific inclusion and exclusion criteria. Five relevant studies were included after screening and critical data analysis. The analyzed studies demonstrated that self-oxygenating composite hydrogel possesses antimicrobial and anti-inflammatory properties, contributing to the reduction of probing depth, gingival bleeding, and plaque index. Additionally, improved tissue healing and regeneration of periodontal tissues were observed, particularly in cases of moderate to severe periodontitis. The application of antimicrobial gel as a complement to conventional mechanical therapy proved effective in improving the clinical parameters of periodontitis. Its antibacterial and regenerative effects, associated with the controlled release of oxygen, present a promising alternative for periodontal treatment, although additional studies are needed to standardize usage protocols and assess its long-term effects.
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Alayadi, H., Talakey, A., Aldulaijan, H., & Shaheen, M. Y. (2024). The Impact of a Topical Oxygen-Releasing Gel (blue®m) on Deep Periodontal Pockets: A Case Report. Medicina (Kaunas, Lithuania), 60(9), 1527. https://doi.org/10.3390/medicina60091527.
Amato, M., Santonocito, S., Polizzi, A., Tartaglia, G. M., Ronsivalle, V., Viglianisi, G., Grippaudo, C., & Isola, G. (2023). Local Delivery and Controlled Release Drugs Systems: A New Approach for the Clinical Treatment of Periodontitis Therapy. Pharmaceutics, 15(4), 1312. https://doi.org/10.3390/pharmaceutics15041312.
Basudan, A. M., Abas, I., Shaheen, M. Y., & Alghamdi, H. S. (2024). Effectiveness of Topical Oxygen Therapy in Gingivitis and Periodontitis: Clinical Case Reports and Review of the Literature. Journal of clinical medicine, 13(5), 1451. https://doi.org/10.3390/jcm13051451.
Di Stefano, M., Polizzi, A., Santonocito, S., Romano, A., Lombardi, T., & Isola, G. (2022). Impact of Oral Microbiome in Periodontal Health and
Periodontitis: A Critical Review on Prevention and Treatment. International journal of molecular sciences, 23(9), 5142. https://doi.org/10.3390/ijms23095142.
Gasmi Benahmed, A., Kumar Mujawdiya, P., Noor, S., & Gasmi, A. (2022). Porphyromonas Gingivalis in the Development of Periodontitis: Impact on Dysbiosis and Inflammation. Archives of Razi Institute, 77(5), 1539–1551. https://doi.org/10.22092/ARI.2021.356596.1875.
Kwon, T., Lamster, I. B., & Levin, L. (2021). Current Concepts in the Management of Periodontitis. International dental journal, 71(6), 462–476. https://doi.org/10.1111/idj.12630.
Leventis, M., Deliberador, T., Alshehri, F., & Alghamdi, H. (2024). Topical oxygen therapy as a novel strategy to promote wound healing and control the bacteria in implantology, oral surgery and periodontology: A review. The Saudi dental journal, 36(6), 841–854. https://doi.org/10.1016/j.sdentj.2024.04.004.
Mattei, B. M., Imanishi, S. A. W., de Oliveira Ramos, G., de Campos, P. S.,Weiss, S. G., & Deliberador, T. M. (2021). Mouthwash with Active Oxygen (blue®m) Reduces Postoperative Inflammation and Pain. Case reports in dentistry, 2021, 5535807. https://doi.org/10.1155/2021/5535807.
Müller-Heupt, L. K., Eckelt, A., Eckelt, J., Groß, J., Opatz, T., & Kommerein, N. (2023). An In Vitro Study of Local Oxygen Therapy as Adjunctive Antimicrobial Therapeutic Option for Patients with Periodontitis. Antibiotics (Basel, Switzerland), 12(6), 990. https://doi.org/10.3390/antibiotics12060990.
Nazir, M., Al-Ansari, A., Al-Khalifa, K., Alhareky, M., Gaffar, B., & Almas, K. (2020). Global Prevalence of Periodontal Disease and Lack of Its
Surveillance. TheScientificWorldJournal, 2020, 2146160. https://doi.org/10.1155/2020/2146160.
Nedumaran, N., & Rajasekar, A. (2024). Clinical and Biochemical Effects of Antioxidant Gel as a Local Drug Delivery Agent in Stage II Grade A Periodontitis Patients: A Prospective Clinical Study. Cureus, 16(6), e61707. https://doi.org/10.7759/cureus.61707.
Nie, M., Yang, J., Rastelli, A. N. S., Shen, Y., & Deng, D. (2023). Oxygen Availability on the Application of Antimicrobial Photodynamic Therapy against Multi-Species Biofilms. Pathogens (Basel, Switzerland), 12(7), 904. https://doi.org/10.3390/pathogens12070904.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [e-book gratuito]. Editora da UAB/NTE/UFSM.
Santos, V. C. E. D., Maquera-Huacho, P. M. Imbriani, M. J. M., Minhaco, V. M. T. R., & Spolidorio, D. M. P. (2023). Effects of BlueM® against Streptococcus mutans biofilm and its virulence gene expression. Brazilian dental journal, 34(1), 19–28. https://doi.org/10.1590/0103-6440202305133.
Shaheen, M. Y., Abas, I., Basudan, A. M., & Alghamdi, H. S. (2024). Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies. Medicina (Kaunas, Lithuania), 60(3), 447. https://doi.org/10.3390/medicina60030447.
Shang, J., Liu, H., Zheng, Y., & Zhang, Z. (2023). Role of oxidative stress in the relationship between periodontitis and systemic diseases. Frontiers in physiology, 14, 1210449. https://doi.org/10.3389/fphys.2023.1210449.
Shitsuka et al. (2014). Matemática fundamental para a tecnologia. Editora Érica.
Sindhusha, V. B., & Rajasekar, A. (2023). Efficacy of Oxygen-Enriched Mouthwash as a Pre-procedural Mouth Rinse Against Oral Microbes Produced During Ultrasonic Scaling. Cureus, 15(11), e49164. https://doi.org/10.7759/cureus.49164.
Takeuchi, Y., Aoki, A., Hiratsuka, K., Chui, C., Ichinose, A., Aung, N., Kitanaka, Y., Hayashi, S., Toyoshima, K., Iwata, T., & Arakawa, S. (2023). Application of Different Wavelengths of LED Lights in Antimicrobial Photodynamic Therapy for the Treatment of Periodontal Disease. Antibiotics (Basel, Switzerland), 12(12), 1676. https://doi.org/10.3390/antibiotics12121676.
Wang, F., Wei, S., He, J., Xing, A., Zhang, Y., Li, Z., Lu, X., Zhao, B., & Sun, B. (2024). Flowable Oxygen-Release Hydrogel Inhibits Bacteria and Treats Periodontitis. ACS omega, 9(48), 47585–47596. https://doi.org/10.1021/acsomega.4c06642.
Zhao, W., Zhang, Y., Chen, J., & Hu, D. (2025). Revolutionizing oral care: Reactive oxygen species (ROS)-Regulating biomaterials for combating infection and inflammation. Redox biology, 79, 103451. https://doi.org/10.1016/j.redox.2024.103451.
Zhu, Y., Xiu, Z., Jiang, X., Zhang, H., Li, X., Feng, Y., Li, B., Cai, R., Li, C., & Tao, G. (2025). Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment. Journal of nanobiotechnology, 23(1), 205. https://doi.org/10.1186/s12951-025-03275-4.
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Copyright (c) 2025 Sarah Karine Araújo Sousa; Valeskah Oliveira da Silva; Julia Larissa Miranda de Almeida; Bárbara Aguiar Lemes; Sérgio Ricardo Rafacho Esteves
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