Effects of DASH and ketogenic diets on metabolic control in women with polycystic ovary syndrome
DOI:
https://doi.org/10.33448/rsd-v14i6.48965Keywords:
Polycystic Ovary Syndrome, Ketogenic Diet, DASH Diet, Nutrition.Abstract
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic condition that affects women of reproductive age and is characterized by hormonal changes, chronic anovulation and insulin resistance. Given the relevance of dietary interventions in the management of this syndrome, this study aims to carry out a literature review to compare the effects of the DASH and ketogenic diets in women with PCOS, in order to identify which of the two strategies has better results on metabolic and hormonal parameters. The search was conducted in the PubMed, SciELO, Google Scholar and BIREME databases, selecting studies published between 2015 and 2025, in Portuguese, English and Spanish. Descriptors such as "Polycystic ovary syndrome", "Síndrome del Ovario Poliquístico", "Síndrome de Stein-Leventhal", "Dieta ketogênica", "ketogenic diet", "Dieta ketogénica", "DASH dietary" and "Mediterranean diet" were used. The results indicate that both diets have positive effects on insulin resistance, body composition and lipid profile, with the ketogenic diet showing greater efficacy in weight loss and glycemic control, while the DASH diet shows sustainable long-term benefits, especially in cardiovascular aspects. It is concluded that both strategies are promising in the management of PCOS, but that it is necessary to individualize the approach according to the profile and clinical response of each patient.
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Akhavan, T., Rastegar, H., Shahbazi, M., et al. (2019). The effects of DASH diet on insulin resistance and serum adiponectin in women with polycystic ovary syndrome: A randomized controlled trial. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(2), 1065–1068. https://doi.org/10.1016/j.dsx.2018.11.051
Alves, M. L. S., Donne, R. D. D., Romano, R. M., & Romano, M. A. (2022). Síndrome de ovários policísticos (SOP), fisiopatologia e tratamento: revisão. Research, Society and Development, 11(9). https://doi.org/10.33448/rsd-v11i9.32469
Azadi-Yazdi, M., Karimi, M., & Khadem-Haghighian, M. (2017). The effect of DASH diet on weight loss and metabolic outcomes in women with polycystic ovary syndrome: A randomized controlled trial. Clinical Nutrition ESPEN, 21, 13–18. https://doi.org/10.1016/j.clnesp.2017.05.003
Barber, T. M., Dimitriadis, G. K., Andreou, A., & Franks, S. (2015). Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance. Clinical Medicine, 15(Suppl 6), s72–s76. https://doi.org/10.7861/clinmedicine.15-6-s72
Casarin, S. T., de Oliveira, S. N., Pillon, S. C., & Gonçalves, N. (2020). Tipos de revisão de literatura: considerações das editoras do Journal of Nursing and Health, 10(5). https://periodicos.ufpel.edu.br/index.php/enfermagem/article/view/19924
Ebbeling, C. B., Feldman, H. A., Klein, G. L., et al. (2022). Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia—a randomized controlled feeding trial. The American Journal of Clinical Nutrition, 115(1), 154–162. https://doi.org/10.1093/ajcn/nqab287
Fernandes, A. C., Lima, M. C. P., & Silva, A. K. da. (2021). Impacto da dieta DASH em parâmetros metabólicos de mulheres com síndrome dos ovários policísticos: Uma revisão integrativa. Revista Brasileira de Nutrição Clínica, 36(2), 142–150. https://www.sbnpe.com.br/revista/2021/impacto-dieta-dash-sop.pdf
Ghanbari, E., Ashourpour, M., & Djafari, F. (2021). DASH diet and its effects on metabolic parameters in women with PCOS: A systematic review and meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 31(6), 1651–1659. https://doi.org/10.1016/j.numecd.2021.02.009
Gil, A. C. (2017). Como elaborar projetos de pesquisa (6ª ed.). Atlas.
Gomes, G. S., Melo, J. V. O., Barros, P. S., et al. (2022). Correlação da resistência à insulina em portadoras da síndrome do ovário policístico. Revista Multidisciplinar em Saúde, 3(4). https://doi.org/10.51161/rems/3577
Greenwell, S., Jones, A., Smith, Y. R., et al. (2024). Protocol for a randomized comparative effectiveness trial comparing a very low-carbohydrate diet to DASH diet for polycystic ovary syndrome: the SUPER (Supporting Understanding of PCOS Education and Research) trial. Trials, 25, 750. https://doi.org/10.1186/s13063-024-08583-y
Hall, K. D. (2017). A review of the carbohydrate–insulin model of obesity. European Journal of Clinical Nutrition, 71, 323–326. https://doi.org/10.1038/ejcn.2016.260
Han, T., Lean, M., & Seidell, J. (2023). Metabolic syndrome and its implications for cardiovascular disease: A review. Obesity Reviews, 24(1), e13456. https://doi.org/10.1111/obr.13456
Juhász, A. E., Stubnya, M. P., Teutsch, B., et al. (2024). Ranking the dietary interventions by their effectiveness in the management of polycystic ovary syndrome: A systematic review and network meta-analysis. Reproductive Health, 21, 28. https://doi.org/10.1186/s12978-024-01758-5
Lagowska, K., Bajerska, J., & Jamka, M. (2018). The role of vitamin D oral supplementation in insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Nutrients, 10(11), 1637. https://doi.org/10.3390/nu10111637
Libre, A. (2018). Síndrome dos ovários policísticos: aspectos clínicos e terapêuticos. https://d1wqtxts1xzle7.cloudfront.net/112795195/11213-libre.pdf
Li, X., Shao, Q., Liu, X., et al. (2017). Effects of ketogenic diet in overweight women with polycystic ovary syndrome. European Journal of Clinical Nutrition, 71(3), 388–392. https://doi.org/10.1038/ejcn.2016.244
Ludwig, D. S. (2023). Carbohydrate-insulin model: Does the conventional view of obesity reverse cause and effect? Philosophical Transactions of the Royal Society B, 378(1888). https://doi.org/10.1098/rstb.2022.0211
Ludwig, D. S., Apovian, C. M., Aronne, L. J., et al. (2022). Competing paradigms of obesity pathogenesis: Energy balance versus carbohydrate-insulin models. European Journal of Clinical Nutrition, 76(9), 1209–1221. https://doi.org/10.1038/s41430-022-01179-2
Ludwig, D. S., & Ebbeling, C. B. (2018). The carbohydrate-insulin model of obesity: Beyond “calories in, calories out”. JAMA Internal Medicine, 178(8), 1098–1103. https://doi.org/10.1001/jamainternmed.2018.2933
Melo, A. S., Macedo, C. S. V., Romano, L. G. M., Ferriani, R. A., & Navarro, P. A. A. S. (2024). Mulheres com síndrome dos ovários policísticos apresentam maior frequência de síndrome metabólica independentemente do índice de massa corpórea. Revista Brasileira de Ginecologia e Obstetrícia. https://doi.org/10.5935/978-65-5848-345-8.C0005
Monget, P., Mazerbourg, S., Pasqueret, E., et al. (2018). Insulin-like growth factor binding proteins and IGFBP proteases: A dynamic system regulating the ovarian folliculogenesis. Frontiers in Endocrinology, 9, 134. https://doi.org/10.3389/fendo.2018.00134
Moran, L., Norman, R. J., Blighted, C., et al. (2015). Lifestyle modifications in women with polycystic ovary syndrome. Cochrane Database of Systematic
Reviews, 7, CD007506. https://doi.org/10.1002/14651858.CD007506.pub3
Oliveira, H. G., Silva, N. P., Garcia, I. A. A., Paiva, B. E. R., & Martins, I. R. R. (2023). A farmacoterapia anticoncepcional e a dieta cetogênica como aliados no tratamento da síndrome de ovários policístico (SOP). Revista Ibero-Americana de Humanidades, Ciências e Educação, 1(1), 10–20. https://doi.org/10.51891/rease.v1i1.10486
Oliveira, L. V. de. (2024). A dieta DASH como alternativa no manejo da síndrome do ovário policístico: uma revisão narrativa (Trabalho de Conclusão de Curso, Graduação em Nutrição). Universidade Federal de São Paulo, Campus Baixada Santista.
Papavasiliou, K., & Papakonstantinou, E. (2017). Nutritional support and dietary interventions for women with polycystic ovary syndrome. Nutrition and Dietary Supplements, 9(1), 63–85. https://doi.org/10.2147/nds.s119738
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica [E-book gratuito]. UAB/NTE/UFSM. https://repositorio.ufsm.br/handle/1/15824
Reis, F., Ribeiro, P., Pereira, V. N., et al. (2017). Ketogenic diet and vitamin D in the treatment of polycystic ovary syndrome: A systematic review. International Journal of Endocrinology and Metabolism, 15(3). https://doi.org/10.5812/ijem.46377
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paulista de Enfermagem, 20(2). https://doi.org/10.1590/S0103-21002007000200001
Oliveira, L. V. de. (2024). A dieta DASH como alternativa no manejo da síndrome do ovário policístico: uma revisão narrativa (Trabalho de Conclusão de Curso, Graduação em Nutrição). Universidade Federal de São Paulo, Campus Baixada Santista.
Sant’Ana, R. C. (n.d.). O efeito dos padrões dietéticos da dieta do mediterrâneo e dieta de baixo índice glicêmico na Síndrome dos Ovários Policísticos (SOP): uma revisão integrativa. [TCC não publicado].
Silva, J. W. G. da. (2022). O uso da dieta mediterrânea na redução da resistência insulínica associada à obesidade: uma revisão da literatura [Trabalho de Conclusão de Curso, UniFTC]. https://repositorio2.uniftc.edu.br/handle/123456789/433
Silva, A. N. C., Silva, L., Hoffmann, T. B., & Lourenço, E. D. (2024). Relação entre síndrome metabólica e síndrome do ovário policístico. NewsLab. https://www.newslab.com.br/wp-content/uploads/yumpu_files/RELAÇÃO-ENTRE-SÍNDROME-METABÓLICA-E-SÍNDROME-DO-OVÁRIO-POLICÍSTICO-1.pdf
Stener-Victorin, E., Padmanabhan, V., Walters, K. A., et al. (2020). Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome. Endocrine Reviews, 41(4), 538–576. https://doi.org/10.1210/endrev/bnaa010
Zohrabi, T., Nadjarzadeh, A., Jambarsan, S., et al. (2023). Effect of Dietary Approaches to Stop Hypertension (DASH) and curcumin on glycemic parameters in polycystic ovary syndrome: Randomized controlled clinical trial. Research Square. https://doi.org/10.21203/rs.3.rs-3610838/v1
Xavier, E. C. S., & Freitas, F. M. N. O. (2021). Manejo dietético e suplementar na fisiopatologia da síndrome dos ovários policísticos: revisão. Research, Society and Development, 10(15). https://doi.org/10.33448/rsd-10i15.22975
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Copyright (c) 2025 Camila Melo Araújo de Moura e Lima; Júlia Pegado da Silva Autonamo; Maria Fernanda Gomes de Castro

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