A study of the biological activity of lavandula angustifolia oil
DOI:
https://doi.org/10.33448/rsd-v14i3.48455Keywords:
Angiogenesis, Anti-angiogenesis, Lavandula angustifolia.Abstract
The use of medicinal plants with therapeutic properties is an ancient practice and continues to be essential in the creation of natural medicines and treatments. According to the World Health Organization (WHO), a large portion of the population in developing countries uses plants for basic health care. Lavender essential oil (Lavandula angustifolia) has several therapeutic properties that make it widely used in pharmaceuticals and aromatherapy. Studies demonstrate that its compounds, such as α-pinene, terpin-4-ol and linalool, have antimicrobial, anti-inflammatory, anxiolytic and antispasmodic effects. In-depth research into these effects is crucial to expanding their safe and effective use in a variety of treatments. This study will be conducted at the Biotechnology Experimental Studies Laboratory of the Pontifical Catholic University of Goiás (PUC-GO), located in Goiânia, after due approval by the institution's Ethics Committee. The main objective of the research is to investigate the effects of lavender essential oil solution (Lavandula angustifolia) on chorioallantoic membranes of embryonated eggs, focusing on identifying angiogenic (stimulating the growth of new blood vessels) or antiangiogenic (inhibiting this growth) activities. Carrying out this study allows a more in-depth understanding of the angiogenic and/or antiangiogenic properties of lavender essential oil, in addition to evaluating its safety for use in the treatment of various diseases within folk medicine. The results are expected to contribute significantly to the development of new products that can have a positive social impact, especially since lavender is an easily accessible, low-cost and renewable plant. Preliminary findings indicate that lavender essential oil has angiogenic activity and that the chorioallantoic membranes used in the tests showed excellent quality, exceeding expectations in quantifying vascularization in each phase of the project. These results reinforce the potential of lavender essential oil as an effective and safe therapeutic alternative.
Downloads
References
Abdala, G. F. S. S., de Paula, I. G., Coelho, E. C. F., Irineu Neto, R.A., Rocha, T. G., Reis, J. M. S. & Paulo, R. M. (2025). O óleo da Maurita flexuosa é angiogênico. Research, Society and Development. 14 (3), e2614348453. Doi: http://dx.doi.org/10.33448/rsd-v14i3.48453.
Agência Nacional de Vigilância Sanitária (ANVISA). (2004, março 16). Resolução RDC nº 48, de 16 de março de 2004. Dispõe sobre o registro de medicamentos fitoterápicos. Diário Oficial da República Federativa do Brasil. Brasília, 18 março 2004. https://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2004/rdc0048_16_03_2004.html
Algieri, F., Rodriguez-Nogales, A., Vezza, T., Garrido-Mesa, J., Garrido-Mesa, N., Pilar Utrilla, M., et al. (2016). Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L. Journal of Ethnopharmacology, 190, 142–158.
Amara, N., Boukhatem, M. N., Ferhat, M. A., Kaibouche, N., Laissaoui, O., & Boufridi, A. (2017). Applications potentielles de l’huile essentielle de lavande papillon (Lavandula stoechas L.) comme conservateur alimentaire naturel. Phytothérapie, 1–9. https://doi.org/[Google Scholar] [CrossRef].
Bicknell, R., et al. (2020). The role of the endothelium in angiogenesis. Journal of Cell Science, 133(19), jcs239246.
Bouyahya, A., Et-Touys, A., Abrini, J., Talbaoui, A., Fellah, H., Bakri, Y., & Bousta, D. (2020). A phytopharmacological review of a Mediterranean plant: Lavandula stoechas L. Clinical Phytoscience.
Bouzouita, N., Kachouri, F., Hamdi, M., & Chaabouni, M. M. (2005). Volatile constituents and antimicrobial activity of Lavandula stoechas L. oil from Tunisia. Journal of Essential Oil Research.
Cavanagh, H. M. A., & Wilkinson, J. M. (2002). Biological activities of lavender essential oil. Phytotherapy Research.
Cragg, G., & Newman, D. J. (2009). Biodiversidade um componente essencial na descoberta de novos fármacos. In Química de Produtos Naturais, Novos Fármacos e a Moderna Farmacognosia (2. ed.). Editora da UNIVALI.
De Francesco, E. M., et al. (2022). Recent advances in targeting angiogenesis in cancer. Cancers, 14(19), 4677.
Ferreira, S. H., et al. (1998). Medicamentos a partir de plantas medicinais no Brasil. Rio de Janeiro: Academia Brasileira de Ciências.
Folkman, J. (2007). Angiogenesis. Annual Review of Medicine, 58, 1-18.
Gören, A. C., Topçu, G., Bilsel, G., Bilsel, M., Aydoğmuş, Z., & Pezzuto, J. M. (2002). The chemical constituents and biological activity of essential oil of Lavandula stoechas ssp. stoechas. Zeitschrift für Naturforschung, 57, 797–800.
Hajhashemi, V., Ghannadi, A., & Sharif, B. (2003). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill. Journal of Ethnopharmacology.
Lima-Neto, G. A., Kaffashi, S., Luiz, W. T., Ferreira, W. R., Dias, D. A. S. YSA, Pazin, G. V., et al. (2015). Quantificação de metabólitos secundários e avaliação da atividade antimicrobiana e antioxidante de algumas plantas selecionadas do Cerrado de Mato Grosso. Revista Brasileira de Plantas Medicinais, 17(supl. 3), 1069–1077. https://doi.org/10.1590/1983-084X/14_161.
Lorenzi, H., & Matos, F. J. A. (2002). Plantas Medicinais no Brasil – Nativas e Exóticas (p. 208-209). Editora do Instituto Plantarum.
Melo-Reis, P. R., et al. (2010). Angiogenic activity of Synadenium umbellatum Pax latex. Brazilian Journal of Biology, 70(1), 189-194.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Editora UAB/NTE/UFSM.
Rahmati, B., Kiasalari, Z., Roghani, M., Khalili, M., & Ansari, F. (2017). Antidepressant and anxiolytic activity of Lavandula officinalis aerial parts hydroalcoholic extract in scopolamine-treated rats. Pharmaceutical Biology.
Rafiee, M., Kiani, Z., Moezi, S. A., & Rad, G. H. M. (2018). The effects of lavender, valerian, and oxazepam on anxiety among hospitalized patients with coronary artery disease. Modern Care Journal.
Vieira, S. (2021). Introdução à bioestatística. Editora GEN/Guanabara Koogan
Vokou, D., Chalkos, D., Karamanlidou, G., & Yiangou, M. (2002). Activation of soil respiration and shift of the microbial population balance in soil as a response to Lavandula stoechas essential oil. Journal of Chemical Ecology.
Zuzarte, M., Goncalves, M. J., Cavaleiro, C., Cruz, M. T., Benzarti, A., Marongiu, B., Maxia, A., Piras, A., & Salgueiro, L. (2013). Antifungal and anti-inflammatory potential of Lavandula stoechas and Thymus herba-barona essential oils. Industrial Crops and Products.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Isadora Garcia de Paula ; Guilherme Fontes de Sousa Skaf Abdala; Eduardo Chaves Ferreira Coelho; Anna Flávia Egito de Melo; Taís Garcia Rocha; Janaína Maria Silva dos Reis; Paulo Roberto de Melo Reis
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
