Bronchiectasia and primary immunodeficiency associated with gastric neoplasm: A case report
DOI:
https://doi.org/10.33448/rsd-v14i3.48532Keywords:
Bronchiectasis, Primary Immunodeficiency Diseases, Pneumonia, Gastric Neoplasms.Abstract
Bronchiectasis is characterized by irreversible dilation of the bronchi, resulting in chronic lung dysfunction and multiple associated complications. There are several causes that can lead to its development, and with the advancement of imaging methods, diagnosis has become increasingly accurate and frequent, even in asymptomatic patients. The objective of this case report was to highlight the association between bronchiectasis in patients with common variable immunodeficiency (CVID) and an increased risk of developing gastric cancer. In addition to the typical pulmonary complaints of this condition, the patient also presented gastrointestinal symptoms. During further investigation, a diagnosis of gastric neoplasia was identified, which led to the indication of gastrectomy. The objective of this report is to alert to the higher incidence of neoplastic diseases in patients with bronchiectasis and CVID, highlighting the importance of early diagnosis. This awareness is essential for the adequate management of these conditions, promoting more effective monitoring and improving the patient's quality of life.
Downloads
References
Barker A. F, & Bardana E. J Jr. (1988). Bronchiectasis: update of an orphan disease. Am Rev Respir Dis. 1988;137(4), 969-78.
Brasil. (2016). Ministério da Saúde. Secretária de Vigilância à Saúde [homepage on the Internet]. Brasília: Ministério da Saúde [cited 2019 Apr 1]. Perfil da morbimortalidade por doenças respiratorias crônicas ́ no Brasil, 2003 a 2013. Boletim Epidemiológico. 2016; 47(19). [Adobe Acrobat document, 9 p.]. Available from: http://portalarquivos2.saude. gov.br/images/pdf/2016/maio/06/2015-026-doencas-respiratoriascronicas.pdf
Brill S. E, Patel A. R, Singh R, Mackay A. J, Brown J. S, & Hurst J. R. (2015). Lung function, symptoms and inflammation during exacerbations of noncystic fibrosis bronchiectasis: a prospective observational cohort study. Respir Res. 2015;16, 16.
Chalmers J. D, Aliberti S, & Blasi F. (2015). Gestão de bronquiectasia em adultos. Eur Respir J 2015; 45, 1446.
Chapel H, Lucas M, Lee M, et al. (2008). Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 2008; 112. 277.
Coutinho D, Fernandes P, Guerra M, Miranda J, & Vouga L. (2016). Surgical treatment of bronchiectasis: A review of 20 years of experience. Rev Port Pneumol (2006). 2016; 22(2), 82-5.
Gao Y. H, Guan W; J, Xu G, Lin Z.Y, Tang Y, Lin Z. M, et al. (2015). The Role of viral infection in pulmonary exacerbations of bronchiectasis in adults: a prospective study. Chest. 2015; 147(6), 1635-1643. https://doi. org/10.1378/chest.14-1961
Hauck F, Voss R, Urban C, Seidel M. G. (2018). Intrinsic and extrinsic causes of malignancies in patients with primary immunodeficiency disorders. J Allergy Clin Immunol 2018; 141, 59.
Lonni S, Chalmers J. D, Goeminne P. C, McDonnell M. J, Dimakou K, De Soyza A, et al. (2015). Etiology of Non-Cystic Fibrosis Bronchiectasis in Adults and Its Correlation to Disease Severity. Ann Am Thorac Soc. 2015;12(12), 1764-70. https://doi.org/10.1513/AnnalsATS.201507- 472OC
Maglione P. J, & Overbey J. R, (2015). Cunningham-Rundles C. Progression of Common Variable Immunodeficiency Interstitial Lung Disease Accompanies Distinct Pulmonary and Laboratory Findings. J Allergy Clin Immunol Pract 2015; 3, 941.
Patel I. S, Vlahos I, Wilkinson T. M, Lloyd-Owen S. J, Donaldson G. C, Wilks M, et al. (2004). Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004; 170(4), 400-7.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Editora UAB/NTE/UFSM.
Polverino E. et. al. (2017). Diretrizes da Sociedade Respiratória Europeia para o tratamento da bronquiectasia em adultos. Revista Respiratória Europeia Set 2017, 50 (3) 1700629; DOI:10.1183/13993003.00629-2017
Polverino E, Cilloniz C, Menendez R, Gabarrus A, Rosales-Mayor E, Alcaraz V, et al. (2015). Microbiology and outcomes of community acquired pneumonia in non cystic-fibrosis bronchiectasis patients. J Infect. 2015; 71(1), 28-36.
Polverino E, Goeminne P. C, McDonnell M. J, et al. (2017). Diretrizes da Sociedade Respiratória Europeia para o tratamento de bronquiectasia em adultos. Eur Respir J 2017; 50.
Quint J. K, Millett E. R, Joshi M, Navaratnam V, Thomas S. L, Hurst J. R, et al. (2016). Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study. Eur Respir J. 2016; 47(1), 186-93.
Reid L. M. (1950). Reduction in bronchial subdivision in bronchiectasis. Thorax. 1950; 5(3), 233-47.
Shapiro R. S. (2011). Malignancies in the setting of primary immunodeficiency: Implications for hematologists/oncologists. Am J Hematol 2011; 86. 48.
Sousa C. K. L, Silva A. C. O, Silva A. L, Carvalho A. S, Mangueira C. C, Abreu L. L. P, Silva W. C. (2019). As evidências científicas da bronquiectasias: Etiologia, Diagnóstico e Formas de tratamento. Braz J Surg Clin Res 2019; 26(3), 78-83
Toassi, R. F. C & Petry, P. C. (2021). Metodologia científica aplicada à área da Saúde. (2 ed;). Editora da UFRGS.
Zullo A, Romiti A, Rinaldi V, Vecchione A, Tomao S, Aiuti F, Frati L, & Luzi G. S. O (1999). Gastric pathology in patients with common variable immunodeficiency. Gut. 1999; 45(1), 77.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Chiara Yasmin Sena Zanella; Andrea Marcia Cunha Acosta
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
