Medication treatment and lifestyle for obesity: An integrative review
DOI:
https://doi.org/10.33448/rsd-v14i1.47970Keywords:
Obesity, Treatment, Lifestyle.Abstract
Obesity is a chronic non-communicable and multifactorial disease associated with the development of comorbidities. As it is one of the leading causes of death worldwide, it has great relevance for public health. Lifestyle and drug treatment are the main non-surgical alternatives for resolving this condition. This integrative review aimed to gather the main findings on drug treatment and lifestyle changes for obesity. The databases searched were PubMed, Web of Science, Scielo, and Lilacs in the past 5 years. For this, the PICOS methodology, the PRISMA protocol, and the Rayyan tool were used for study selection and inclusion. After reading the abstracts, full texts, and applying the inclusion and exclusion criteria, 6 studies remained for quantitative synthesis. It was noted that through self-monitoring of caloric intake and physical activity, cognitive-behavioral therapy (CBT) helps patients manage their goals and harmful behaviors, thus improving their eating and physical habits. Patients undergoing pharmacological treatment achieved overall physical and laboratory exam results similar to those who chose to change their lifestyle for the same purpose. Lifestyle changes, with nutritional and physical exercise instructions, CBT, and herbal pharmacological treatment are effective and safe, providing positive modifications, especially concerning the reduction of risks and consequences caused by obesity.
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References
Amiri, S., & Behnezhad, S. (2019). Obesity and anxiety symptoms: a systematic review and meta-analysis. Neuropsychiatry, 33(2), 72–89. https://doi.org/10.1007/s40211-019-0302-9
Anima. (2014). Manual revisão bibliográfica sistemática integrativa: a pesquisa baseada em evidências. Grupo Anima. https://biblioteca.cofen.gov.br/wp-content/uploads/2019/06/manual_revisao_bibliografica-sistematica-integrativa.pdf.
Barakat, B., & Almeida, M. E. F. (2021). Biochemical and immunological changes in obesity. Archives of biochemistry and biophysics, 708, 108951. https://doi.org/10.1016/j.abb.2021.108951
Crossetti, M. G. M. (2012). Revisión integradora de la investigación em enfermaría el rigor científico que se le exige. Rev. Gaúcha Enferm. 33(2): 8-9... 5.3).
Duarte, A.P.N.B., Govato, T. C. P., Carvalho, R. G., Pontes-Junior, L. C. B., Rodrigues, C. L., Santos, G. M. P., Nicolau, L. A. D., Ferraz, R. R. N., & Menezes-Rodrigues, F. S. (2020). Uso de anfepramona, femproporex, mazindol e sibutramina no Tratamento de pacientes com sobrepeso ou obesidade: análise Farmacológica e clínica. International Journal of Health Management Review, 6(2). https://doi.org/10.37497/ijhmreview.v6i2.210
Fonseca, A. de F. C., Miranda, T. C. de A., & Silva, E. F. (2024). O manejo medicamentoso e nutricional da obesidade: Uma análise comparativa. RBONE - Revista Brasileira De Obesidade, Nutrição E Emagrecimento, 18(113), 378-394. https://www.rbone.com.br/index.php/rbone/article/view/2408
Gillespie, J., Wright, H., Pinkney, J., & Lloyd, H. (2024). Blending Behavioural Theory and Narrative Analysis to Explore the Lived Experience of Obesity and Assess Potential Engagement in a UK Weight Management Service: Theory and Narrative Approaches in Weight Management. Healthcare, 12(7), 747–747. https://doi.org/10.3390/healthcare12070747
Gomes, A. O. R., Oliveira, V. D., & Mosquito, D. C. L. (2022) Utilização da Garcinia cambogia no tratamento da obesidade: estudo de revisão. Revista Brasileira de Plantas Medicinais, 170-179. https://www.sbpmed.org.br/admin/files/papers/file_dKxNLUzkUNjP.pdf.
Gonçalves, L. S. dos R., & Abreu, T. P. de. (2021). O uso off label de medicamentos para o tratamento da obesidade no Brasil. Revista Ibero-Americana de Humanidades, Ciências E Educação, 7(10), 1165–1177. https://doi.org/10.51891/rease.v7i10.2654
Hannan, M., Kringle, E., Hwang, C. -L., & Laddu, D. (2021). Behavioral Medicine for Sedentary Behavior, Daily Physical Activity, and Exercise to Prevent Cardiovascular Disease: A Review. Current Atherosclerosis Reports, 23(9). https://doi.org/10.1007/s11883-021-00948-x
Höchsmann, C., Dorling, J. L., Martin, C. K., Newton, R. L., Apolzan, J. W., Myers, C. A., Denstel, K. D., Mire, E. F., Johnson, W. D., Zhang, D., Arnold, C. L., Davis, T. C., Fonseca, V., Lavie, C. J., Price-Haywood, E. G., & Katzmarzyk, P. T. (2021). Effects of a 2-Year Primary Care Lifestyle Intervention on Cardiometabolic Risk Factors. Circulation, 143(12), 1202–1214. https://doi.org/10.1161/circulationaha.120.051328
Jacobs, M., Harris, J., Craven, K., & Sastre, L. (2020). Sharing the ‘weight’ of obesity management in primary care: integration of registered dietitian nutritionists to provide intensive behavioural therapy for obesity for Medicare patients. Family Practice. https://doi.org/10.1093/fampra/cmaa006
Kheniser, K., Saxon, D. R., & Kashyap, S. R. (2021). Long-Term Weight Loss Strategies for Obesity. The Journal of Clinical Endocrinology & Metabolism, 106(7), 1854–1866. https://doi.org/10.1210/clinem/dgab091
Langan, A., Bader, A., Goedkoop, S., Cummings, S., Tsikitas, M., Nogueira, I., Campoverde Reyes, K. J., & Stanford, F. C. (2020). A longitudinal study to investigate the effects of a 12-week comprehensive lifestyle weight management program on body weight and quality of life. Clinical Nutrition ESPEN, 40, 125–132. https://doi.org/10.1016/j.clnesp.2020.10.002
Leite, F. R., Queiroz, A. T., Sousa, M. R. de., & Maia, L. M. de O. (2023). Uma abordagem geral da obesidade e seu tratamento. Revista Eletrônica Acervo Saúde, 23(5). https://doi.org/10.25248/reas.e12798.2023
Mambrini, S. P., Menichetti, F., Ravella, S., Pellizzari, M., De Amicis, R., Foppiani, A., Battezzati, A., Bertoli, S., & Leone, A. (2023). Ultra-Processed Food Consumption and Incidence of Obesity and Cardiometabolic Risk Factors in Adults: A Systematic Review of Prospective Studies. Nutrients, 15(11). https://doi.org/10.3390/nu15112583
Mattos, P. C. (2015). Tipos de revisão de literatura. Unesp, 1-9. Recuperado de https://www.fca.unesp.br/Home/Biblioteca/tipos-de-evisao-de-literatura.pdf.
Monteiro, C. A., & Cannon, G. (2021). Yes, food portion sizes and people have become bigger and bigger. What is to be done? American Journal of Public Health, 111(12), 2091–2093. https://pubmed.ncbi.nlm.nih.gov/34878862/
Morys, F., Dadar, M., & Dagher, A. (2021). Association Between Midlife Obesity and Its Metabolic Consequences, Cerebrovascular Disease, and Cognitive Decline. The Journal of Clinical Endocrinology & Metabolism, 106(10), e4260–e4274. https://doi.org/10.1210/clinem/dgab135
Murakami, J. M., Bennett, B. L., Rand-Giovannetti, D., Stefano, E. C., & Latner, J. D. (2020). Enhancing employee wellness: Translating an effective community behavioral weight-loss treatment to the worksite. Nutrition and health, 26(3), 215–223. https://doi.org/10.1177/0260106020926834
Muscella, A., Stefàno, E., Lunetti, P., Capobianco, L., & Marsigliante, S. (2020). The Regulation of Fat Metabolism During Aerobic Exercise. Biomolecules, 10(12). https://doi.org/10.3390/biom10121699
Neeland, I. J., Ross, R., Després, J.-P., Matsuzawa, Y., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., Cuevas, A., Hu, F. B., Griffin, B., Zambon, A., Barter, P., Fruchart, J.-C., & Eckel, R. H. (2019). Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: A position statement. The Lancet Diabetes & Endocrinology, 7(7), 715–725. https://doi.org/10.1016/S2213-8587(19)30084-1
Piché, M. E., Tchernof, A., & Després, J. P. (2020). Obesity phenotypes, diabetes, and cardiovascular diseases. Circulation Research, 126(11), 1477–1500. https://doi.org/10.1161/circresaha.120.316101
Raja, M., Nayak, C., Paital, B., & Rath P. (2020). Randomized trial on weight and lipid profile of obese by formulation from Garcinia cambogia. Medical Science, 24(103), 1000–1009. https://www.researchgate.net/publication/343206710_ARTICLE_Randomized_trial_on_weight_and_lipid_profile_of_obese_by_formulation_from_Garcinia_cambogia_Corresponding_author_Medical_Science
Safaei, M., Sundararajan, E. A., Driss, M., Boulila, W., & Shapi'i, A. (2021). A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity. Computational Biology and Medicine, 136. https://doi.org/10.1016/j.compbiomed.2021.104754
Santos, C. M. C., Pimenta, C. A. M., & Nobre, M. R. C. (2007). The PICO strategy for the research question construction and evidence search. Revista Latino-Americana de Enfermagem, 15(3), 508–511. https://doi.org/10.1590/s0104-11692007000300023
Trabulsi, R. K., Oliveira, A. F. dos S. M., Bezerra, C. M. F. M. de C., Lima, J. B., Sousa, C. E. da S., Pacheco, I. A., Gusmao, E. E. S., Castro, C. de F., Silva, V. P., Sousa, S. M. C. de, & Álvares, R. F. (2023). As consequências clínicas do uso de Ozempic para tratamento da obesidade: uma revisão de literatura. Brazilian Journal of Health Review, 6(3), 12297–12312. https://doi.org/10.34119/bjhrv6n3-305
Van Baak, M. A., Pramono, A., Battista, F., Beaulieu, K., Blundell, J. E., Busetto, L., Carraça, E. V., Dicker, D., Encantado, J., Ermolao, A., Farpour-Lambert, N., Woodward, E., Bellicha, A., & Oppert, J. M. (2021). Effect of different types of regular exercise on physical fitness in adults with overweight or obesity: Systematic review and meta-analyses. Obesity reviews, 22. https://doi.org/10.1111/obr.13239
Wadden, T.A., Tronieri, J.S., & Butryn, M.L. (2020). Lifestyle modification approaches for the treatment of obesity in adults. American Psychologist, 75(2), 235-251. https://doi.org/10.1037/amp0000517
World Health Organization. (2024, 1 de março). Obesity and overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
World Health Organization. (2024, 1 de março). One in eight people are now living with obesity. https://www.who.int/news/item/01-03-2024-one-in-eight-people-are-now-living-with-obesity
Wu, Y., & Ma, Z. (2023). Exercise Intervention Based on Behavioral Change Theory: Influence on Body Morphology and Body Composition. Alternative therapies in health and medicine, 29, 150-155. https://pubmed.ncbi.nlm.nih.gov/36074962/
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Copyright (c) 2025 Raíssa Gabrielle Alves Silva ; Bárbara Adeline Ramalho Faro; Bruna Mendonça Dória de Jesus; Maria Fernanda Lima Bezerra Santos; Victoria Solange Novais de Barros Costa ; Yasmin Gabriele Ferreira Santos ; Fernanda Kelly Fraga Oliveira; Aline Barreto Hora

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