Smoking and periodontitis: a challenge for the immune response

Authors

DOI:

https://doi.org/10.33448/rsd-v14i5.48737

Keywords:

Smoking, Periodontitis, Immune System.

Abstract

Smoking is one of the most prevalent addictions worldwide. It alters the patient's immune response against periodontopathogenic microorganisms, compromising the defense system and potentially triggering periodontal collapse, periodontitis. Periodontitis and smoking have a major impact on the immune system, posing a huge challenge to the patient's health and well-being. Therefore, it is extremely important for dentists to understand the impacts of smoking on patients with periodontitis, so that they can establish a better diagnosis and prognosis, in addition to raising patient awareness and encouraging them to quit smoking. The objective of this review was to validate the immunoinflammatory relationship between smoking and periodontitis in order to provide scientific knowledge that supports decision-making in order to promote health. An integrative literature review was carried out, selecting 8 articles, according to the exclusion criteria, to answer the guiding question "What is the immunoinflammatory influence of smoking on periodontitis and the consequences for periodontal health?" CONCLUSION: Smoking appears to exacerbate the local inflammatory response by increasing pro-inflammatory cytokines such as IL-1β, deregulating the balance of bone remodeling mediators such as RANKL/OPG, and altering the composition of the oral microbiota, favoring pathogenic species. In addition, smoking modulates the adaptive immune response, affecting the levels of antibodies against periodontal and commensal pathogens, and may interfere with the production of antimicrobial peptides important in host defense, increasing the prevalence, severity, and progression of periodontitis.

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References

Anima. (2014). Manual revisão bibliográfica sistemática integrativa: a pesquisa baseada em evidências. Grupo Anima. https://biblioteca.cofen.gov.br/wp-content/uploads/2019/06/manual_revisao_bibliografica-sistematica-integrativa.pdf

Behfarnia, P., Saied-Moallemi, Z., Javanmard, SH, & Naseri, R. (2016). Serum, saliva, and GCF concentration of RANKL and osteoprotegerin in smokers versus nonsmokers with chronic periodontitis. Advanced biomedical research, 5(1), 80.

Brasil. (2020). Protocolo clínico e Diretrizes terapêuticas do tabagismo. Ministério da Saúde.

Chang, J., Meng, H. W., Lalla, E., & Lee, C. T. (2021) The impact of smoking on non‐surgical periodontal therapy: A systematic review and meta‐analysis. Journal of Clinical Periodontology, 48(1), 61-76.

Chatzopoulos, G. S., Jiang, Z., Marka, N., & Wolff, L. F. (2023). Association between Periodontitis Extent, Severity, and Progression Rate with Systemic Diseases and Smoking: A Retrospective Study. Journal of Personalized Medicine, 13(5), 814.

Crossetti, M. G. M. (2012). Revisión integradora de la investigación en enfermería el rigor científico que se le exige. Maria Da Graça Oliveira Crossetti. Rev. Gaúcha Enferm. 33 (2): 8-9.

Dias, P. F. (2016). Sistema Rankl/Rank/OPG e o seu papel na reabsorção óssea na periodontite crónica. Dissertação de Mestrado. Egas Moniz School of Health & Science (Portugal).

Ebersole, J. L., Steffen, M. J., Thomas, M. V., & Al‐Sabbagh, M. (2014). Smoking‐related cotinine levels and host responses in chronic periodontitis. Journal of periodontal Research, 49 (5), 642-651.

Hayman, L., Steffen, M. J., Stevens, J., Badger, E., Tempro, P., Fuller, B., ... & Ebersole, J. L. (2011). Smoking and periodontal disease: discrimination of antibody responses to pathogenic and commensal oral bacteria. Clinical & Experimental Immunology, 164(1), 118-126.

Le Foll, B., Piper, M. E., Fowler, C. D., Tonstad, S., Bierut, L., Lu, L., ... & Hall, W. D. (2022). Tobacco and nicotine use. Nature Reviews Disease Primers, 8 (1), 19.

Machado, V., Lopes, J., Patrão, M., Botelho, J., Proença, L., & Mendes, JJ. (2020). Validity of the association between periodontitis and female infertility conditions: a concise review. Reproduction, 160(3), R41-R54. doi: 10.1530/REP-20-0176.

Medeiros, G. V. P., & Dias, K. S. P. A. (2018). A influência do tabagismo na doença periodontal: Uma revisão de literatura. Revista de psicologia, 12(40), 470-9.

Meenawat, A., Govila, V., Goel, S., Verma, S., Punn, K., Srivastava, V., & Dolas, R. S. (2015). Evaluation of the effect of nicotine and metabolites on the periodontal status and the mRNA expression of interleukin-1β in smokers with chronic periodontitis. Journal of Indian Society of Periodontology, 19(4), 381-7.

Newman, M. G., Carranza, F. A., Takei, H. H., & Klokkevold, P. R. (Eds.). (2006). Carranza's clinical periodontology. Elsevier Brasil.

Oliveira, L. V., de Almeida Dantas, P. P., Casarin, M., Pola, N. M., Martins, T. M., & Muniz, F. W. M. G. (2023). Tratamento de periodontite estágio III localizado grau C em um indivíduo fumante: um relato de caso. Revista da Faculdade de Odontologia-UPF, 28(1). https://doi.org/10.5335/rfo.v28i1.15078

Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., ... & Tonetti, M. S. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of periodontology, 89, S173-S182.

Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.

Prince, Y., Davison, G. M., Davids, S. F., Erasmus, R. T., Kengne, A. P., Raghubeer, S., & Matsha, T. E. (2024). The effect of cigarette smoking on the oral microbiota in a South African population using subgingival plaque samples. Heliyon, 10(10), e31559. doi: 10.1016/j.heliyon.2024.e31559.

Rioboo Crespo, M., & Bascones, A. (2005). Factores de riesgo de la enfermedad periodontal: factoresgenéticos. Avances en periodoncia e implantología oral, 17 (2), 69-77.

Soldati, K. R., Gutierrez, L. S., Anovazzi, G., Scarel-Caminaga, R. M., & Zandim-Barcelos, D. L. (2022). mpact of smoking on protein levels of beta-defensins in periodontal disease. Brazilian Dental Journal, 33 (4), 79-86.

Warnakulasuriya, S., Dietrich, T., Bornstein, M. M., Peidró, E. C., Preshaw, P. M., Walter, C., ... & Bergström, J. (2010). Oral health risks of tobacco use and effects of cessation. International dental journal, 60 (1), 7-30.

Zasimauskas, D., & Žekonis, G. (2008). Effect of smoking on neutrophil oxidative metabolism. Medicina, 44(3), 195.

Zasimauskas, D., & Žekonis, G. (2005). The Response of Peripheral Blood Neutrophils Unstimulated and Stimulated by Prodigiosan to Smoking. Stomatologija, 7 (2), 48-51. 11)

Published

2025-05-04

Issue

Section

Health Sciences

How to Cite

Smoking and periodontitis: a challenge for the immune response. Research, Society and Development, [S. l.], v. 14, n. 5, p. e1814548737, 2025. DOI: 10.33448/rsd-v14i5.48737. Disponível em: https://ojs34.rsdjournal.org/index.php/rsd/article/view/48737. Acesso em: 28 jun. 2025.