Noncardiac chest pain: The role of costochondritis in differential diagnosis
DOI:
https://doi.org/10.33448/rsd-v14i3.48538Keywords:
Chest Pain, Cartilage Diseases, Differential Diagnosis.Abstract
Introduction: Noncardiac chest pain (NCT) is a common complaint in clinical practice, often resulting in emergency consultations. Although the initial investigation aims to exclude cardiac causes, costochondritis represents an important musculoskeletal etiology, often underdiagnosed, whose recognition is essential to avoid unnecessary invasive examinations and provide appropriate treatment. Objective: The present study aims to explore the contribution of costochondritis in the differential diagnosis of NCT, emphasizing its pathophysiology, diagnostic criteria and clinical management. Methodology: An integrative review of the literature was carried out in indexed databases such as PubMed MEDLINE, SCIELO, Ebscohost, Google Scholar and the Virtual Health Library (VHL), using the descriptors "Noncardiac chest pain", "Costochondritis" and "Differential diagnosis". Articles published between 2009 and 2024 were selected, prioritizing clinical studies, systematic reviews, and international guidelines, with critically analyzed data, focusing on clinical presentation, diagnosis, and therapeutic strategies. Results and Discussion: The review demonstrated that costochondritis is responsible for up to 30% of cases of NCDT, with the diagnosis being eminently clinical, based on localized pain on palpation of the sternocostal joints, without systemic inflammatory signs. Treatment includes analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and physical measures, with emerging evidence on the use of physiotherapy techniques for symptomatic relief. Conclusion: It is concluded that costochondritis is a relevant cause of NCDT and should be considered in the differential diagnosis, especially after ruling out cardiovascular causes.
Downloads
References
Alexander, R. (2022). Acupuncture appears to be a rapidly effective treatment for costochondritis. Acupuncture in Medicine, 40(1), 99-100.
Barbosa, A. C., Silva, A. S., Cordeiro, A. A., Ribeiro, B. N., Pedra, F. R., Borges, I. N., ... & Serufo, J. C. (2010). Diagnóstico diferencial da dor torácica: ênfase em causas não coronarianas. Rev Med Minas Gerais, 20(2), 24-9.
Barros, A. L., Carvalho, G. P., Amorim, M. E. M., Evangelista, M. L. B., Gomes, M. F. B., dos Santos, W. C. A., ... & Silva, C. F. (2024). Abordagem ao paciente com dor torácica na emergência. Brazilian Journal of Implantology and Health Sciences, 6(8), 4086-4099.
Bolandrini, A., Totti, V., Segat, M., Zaninetti, M., Fascia, M., Segat, A., ... & Galeoto, G. (2024). Costochondritis syndrome and thoracic-chest related pain: a scoping review. medRxiv, 2024-02.
Castro, L. F. D. S. O., Pitanga, L. S., Miranda, C. M., Berbem, B. Q. C., da Costa, M. J. R., Zoccoli, T. B. V., ... & de Sousa, R. M. A. (2024). Abordagem avançada na gestão da dor torácica aguda: avaliação e direcionamento de condutas no setor de emergência. Revista Eletrônica Acervo Saúde, 24(6), e16728-e16728.
Gava, F. D., Sant’Anna, G. S., Lopes, R. N., de Oliveira, K. O. P., Souza, B. T., Brandão, K. F., ... & Araújo, G. R. C. (2023). Abordagem do diagnóstico diferencial de dor torácica na emergência. Brazilian Journal of Implantology and Health Sciences, 5(5), 6133-6142.
Ghandi, Y., Habibi, D., & Mohajer, O. (2021). Assessment of correlation between costochondritis and vitamin d insufficiency in school-age children. Journal of Comprehensive Pediatrics, 12(3).
Fabián González, D. J., Sánchez Cortázar, J., & Gómez Pérez, M. D. G. (2022). Síndrome de Tietze. Acta médica Grupo Ángeles, 20(2), 199-200.
Guevara, P. P. P. L., Vadillo Santos, A., Avila Perfino, M. D., & Gómez Pérez, M. D. G. (2024). Síndrome de Tietze como una entidad rara y benigna de dolor torácico. Acta médica Grupo Ángeles, 22(1), 62-64.
Lazaro, A., & Ahmed, M. S. (2017). Costochondritis. Musculoskeletal Sports and Spine Disorders: A Comprehensive Guide, 171-173.
Lin, K., & Tung, C. (2017). Integrating acupuncture for the management of costochondritis in adolescents. Medical Acupuncture, 29(5), 327-330.
Mott, T., Jones, G., & Roman, K. (2021). Costochondritis: rapid evidence review. American Family Physician, 104(1), 73-78.
Proulx, A. M., & Zryd, T. W. (2009). Costochondritis: diagnosis and treatment. American Family Physician, 80(6), 617-620.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.
Rees, C. J., Cantor, R. M., Pollack Jr, C. V., & Riese, V. G. (2019). Costochondritis. Differential Diagnosis of Cardiopulmonary Disease: A Handbook, 311-317.
Samimi, K. (2021). An overview of costochondral disorders (Master’s thesis). Boston University School of Medicine.
Schumann, J. A., Sood, T., & Parente, J. J. (2024). Costochondritis. In StatPearls [Internet]. StatPearls Publishing.
Segalla, A. V. Z., Santos, B. P., Reis, D. D., & Meneguin, S. (2023). Fatores determinantes de prioridade de atendimento na classificação de risco a pacientes com dor torácica. Revista Gaúcha de Enfermagem, 44, e20220100.
Soetartio, I. M., Susanto, A. D., Soehardiman, D., & Antariksa, B. (2021). Chest wall syndrome. Respiratory Science, 2(1), 55-63.
Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8, 102-106.
Wani, M. A., Shah, N. N., Khursheed, S. Q., Dar, K. A., & Bashir, A. (2016). Tuberculosis presenting as costochondritis: a rare case report and brief review of literature. British Journal of Medical Practitioners, 9(2), 26-29.
Yoshiyama, N., Tsuneyoshi, S., Nishi, J. I., & Ishii, H. (2021). Infective costochondritis and multiple abscesses in a healthy adult. BMJ Case Reports, 14(1), e240948.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 André Gerra Passos; Amanda Cristina da Costa Lopes; Gabriel Gurgel Lago; Jorge Antônio de Moura Leite; Ana Luiza Zampar Quintana Gomes

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.