The anti-inflammatory effect of turmeric on inflammatory bowel diseases

Authors

DOI:

https://doi.org/10.33448/rsd-v14i6.48985

Keywords:

Turmeric, Curcumin, Intestine, Polyphenols, Inflammation.

Abstract

Dysbiosis of the intestinal microbiota plays an important role in the development of diseases such as ulcerative colitis and Crohn's disease. Thus, turmeric longa can help in the treatment of these diseases, due to its anti-inflammatory and antioxidant action. The objective of the study was to analyze the consumption of turmeric longa in people with inflammatory bowel diseases, verify the reduction of side effects with the use of turmeric and report its effects on gastrointestinal health. The methodology is a literature review study taking into account an analysis of scientific articles that address the topic exposed in the EBSCO, CAPES and PubMed databases. National and international studies in English and Portuguese, from the last 10 years, were selected. The search methodology was carried out using the following descriptors: (curumim AND dysbiosis) OR (curumim and intestine) OR (curumim AND inflammation). After analyzing the studies, it was found that this herbal medicine had a preventive action on the intestinal inflammatory response, repairs the intestinal microbiota and can prevent early infections by bacteria, enriching the diversity of the intestinal microbiota. This study allowed us to understand that turmeric longa can treat inflammatory bowel diseases by modulating the intestinal microbiota, but requires further studies.

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References

Anima. (2014). Manual revisão bibliográfica sistemática integrativa: a pesquisa baseada em evidências. Grupo Anima. https://biblioteca.cofen.gov.br/wp-content/uploads/2019/06/manual_revisao_bibliografica-sistematica-integrativa.pdf

Boroumand, N., Samargandian, S., & Hashemy, S. I. (2018). Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. Journal of Herbmed Pharmacology, 7(4), 211–219. https://doi.org/10.15171/jhp.2018.33

Cho, J. A., & Park, E. (2015). Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion. Nutrition Research and Practice, 9(2), 117. https://doi.org/10.4162/nrp.2015.9.2.117

Cristina, F., Franco, F. C. Z., de Oliveira, M. C. C., Gaburri, P. D., Franco, D. C. Z., & Chebli, J. M. F. (2022). High prevalence of non-adherence to ulcerative colitis therapy in remission: Knowing the problem to prevent loss. Arquivos de Gastroenterologia, 59(1), 40–46. https://doi.org/10.1590/S0004-2803.202200001-08

Crossetti, M. G. M. (2012). Revisión integradora de la investigación en enfermería el rigor científico que se le exige. Maria Da Graça Oliveira Crossetti. Rev. Gaúcha Enferm.33(2):8-9

Cruz-Correa, M., Shoskes, D., Sanchez, P., Zhao, R., Hylind, L. M., Wexner, S. D., Giardiello, F. M., & Sidransky, D. (2018). Efficacy and safety of curcumin in treatment of intestinal adenomas in patients with familial adenomatous polyposis. Gastroenterology, 155(3), 668–673. https://doi.org/10.1053/j.gastro.2018.05.031

Franco, F. C. Z., de Oliveira, M. C. C., Gaburri, P. D., Franco, D. C. Z., & Chebli, J. M. F. (2022). High prevalence of non-adherence to ulcerative colitis therapy in remission: Knowing the problem to prevent loss. Arquivos de Gastroenterologia, 59(1), 40–46. https://doi.org/10.1590/S0004-2803.202200001-08

Firoz, H. M., Rahman, M. M., Islam, M. S., & Islam, M. R. (2023). Antiproliferative activity and apoptosis-inducing mechanism of Curcuma longa (Turmimax®) on HeLa cell lines. Brazilian Journal of Biology, 83, e275953. https://doi.org/10.1590/1519-6984.275953

Ghumann, S. A., Iqbal, J., Ahmad, B., & Iqbal, M. S. (2023). Formulation and characterization of curcumin niosomes: Antioxidant and cytotoxicity studies. Pharmaceuticals, 16(10), 1406. https://doi.org/10.3390/ph16101406

Giacosa, A., Morazzoni, P., Bombardelli, E., Riva, A., Bianchi Porro, G., & Rondanelli, M. (2022). Beneficial effects on abdominal bloating with an innovative food-grade formulation of Curcuma longa and Boswellia serrata extracts in subjects with irritable bowel syndrome and small bowel dysbiosis. Nutrients, 14(3), 416. https://doi.org/10.3390/nu14030416

Henriques, D., Lopes, S., Faria, G., & Parente, M. P. L. (2022). Complementary and alternative medicine use in Brazilian patients with inflammatory bowel disease. Arquivos de Gastroenterologia, 59(3), 375–382. https://doi.org/10.1590/S0004-2803.202203000-68

Kothapally, S., Tripathi, A., & Rao, N. (2022). Superior bioavailability of a novel curcumin formulation in healthy humans under fasting conditions. Advances in Therapy, 39(5), 2128–2138. https://doi.org/10.1007/s12325-022-02081-w

Lang, A., Salomon, N., Wu, J. C., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J. Y. L., Cheong, P. K., Avidan, B., Gamus, D., & Chowers, Y. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology and Hepatology, 13(8), 1444–1449.e1. https://doi.org/10.1016/j.cgh.2015.02.019

Loganes, C., Di Silvestro, S., Soverini, V., & Guglielmetti, S. (2017). Curcumin anti-apoptotic action in a model of intestinal epithelial inflammatory damage. Nutrients, 9(6), 578. https://doi.org/10.3390/nu9060578

Lopresti, A. L., Smith, S. J., & Malvi, H. (2021). Efficacy of a curcumin extract (CurcugenTM) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: A randomised, double-blind, placebo-controlled study. BMC Complementary Medicine and Therapies, 21(1), 1–14. https://doi.org/10.1186/s12906-021-03220-6

Magalhães, F. C. B., Souza, A. S., & Figueiredo, F. A. (2023). Doença de Crohn: revisão e padronização da nomenclatura. Radiologia Brasileira, 56(2), 95–101. https://doi.org/10.1590/0100-3984.2022.0082

Nabavi, S. F., Daglia, M., Moghaddam, A. H., Habtemariam, S., & Nabavi, S. M. (2014). Curcumin and liver disease: From chemistry to medicine. Comprehensive Reviews in Food Science and Food Safety, 13(1), 62–77. https://doi.org/10.1111/1541-4337.12047

Pan, M. H., Lai, C. S., & Ho, C. T. (2017). Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function. Journal of Complementary and Integrative Medicine, 14(3). https://doi.org/10.1515/jcim-2015-0107

Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Ed.UAB/NTE/UFSM. 10)

Purpura, M., Jäger, R., Joy, J. M., Lowery, R. P., & Wilson, J. M. (2018). Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects. European Journal of Nutrition, 57, 929–938. https://doi.org/10.1007/s00394-016-1376-9

Ried, K., Travica, N., & Sali, A. (2020). Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders. Nutrition Research, 76, 37–51. https://doi.org/10.1016/j.nutres.2020.02.008

Rocha, D. A., & Ferraz, A. R. (2023). Uso da cúrcuma no tratamento da doença inflamatória intestinal (DII): Uma revisão integrativa. Revista Ibero-Americana de Humanidades, Ciências e Educação, 9(5), 2171–2183. https://doi.org/10.51891/rease.v9i5.9962

Sadeghi, N., Mansoori, A., Shayesteh, A. A., & Hashemi, S. J. (2019). The effect of curcumin supplementation on clinical outcomes and inflammatory markers in patients with ulcerative colitis. Phytotherapy Research, 34(5), 1123–1133. https://doi.org/10.1002/ptr.6581

Santos, G. M., Silva, L. R., & Santana, G. O. (2014). Repercussões nutricionais em crianças e adolescentes na presença de doenças inflamatórias intestinais. Revista Paulista de Pediatria, 32(4), 403–411. https://doi.org/10.1016/j.rpped.2014.04.008

Santos, R. M., Coelho, R. S., & Almeida, L. M. (2017). Inflammatory bowel disease: Outpatient treatment profile. Arquivos de Gastroenterologia, 54(2), 96–100. https://doi.org/10.1590/S0004-2803.201700000-01

Scazzocchio, B., Minghetti, L., & D’Archivio, M. (2020). Interaction between gut microbiota and curcumin: A new key of understanding for the health effects of curcumin. Nutrients, 12(9), 2499. https://doi.org/10.3390/nu12092499

Singh, D. N., Kumar, M., & Singh, R. (2023). Common foods for boosting human immunity: A review. Food Science and Nutrition, 11(11), 6761–6774. https://doi.org/10.1002/fsn3.3628

Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-339.

Sueth-Santiago, V., Silva, N. C. G., & Oliveira, A. E. (2015). Curcumin, the golden powder from turmeric: Insights into chemical and biological activities. Química Nova, 38(2), 145–158. https://doi.org/10.5935/0100-4042.20150035

Sugimoto, K., Hanai, H., Tozawa, K., Arai, H., Sugimoto, K., & Uchino, M. (2020). Highly bioavailable curcumin derivative ameliorates Crohn’s disease symptoms: A randomized, double-blind, multicenter study. Journal of Crohn's and Colitis, 14(12), 1693–1701. https://doi.org/10.1093/ecco-jcc/jjaa097

Uchio, R., Hirose, Y., Murosaki, S., & Yamamoto, Y. (2021). Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: A randomized, double-blind, placebo-controlled trial. Nutrition Journal, 20(1), 1–12. https://doi.org/10.1186/s12937-021-00748-8

Urošević, M., Djordjevic, A., & Kolarevic, A. (2022). Curcumin: Biological activities and modern pharmaceutical forms. Antibiotics, 11(2), 135. https://doi.org/10.3390/antibiotics11020135

Varì, R., Scazzocchio, B., & D’Archivio, M. (2021). Obesity-associated inflammation: Does curcumin exert a beneficial role, Nutrients, 13(3), 1021. https://doi.org/10.3390/nu13031021

Vecchi Brumatti, L., Marcuzzi, A., Tricarico, P. M., Zanin, V., Girardelli, M., Bianco, A. M., & Crovella, S. (2014). Curcumin and inflammatory bowel disease: Potential and limits of innovative treatments. Molecules, 19(12), 21127–21153. https://doi.org/10.3390/molecules191221127

Witika, B. A., Makoni, P. A., & Parani, S. (2021). Enhancement of biological and pharmacological properties of an encapsulated polyphenol: Curcumin. Molecules, 26(14), 4244. https://doi.org/10.3390/molecules26144244

Zhang, B., Wang, X., & Li, Y. (2022). Gut microbiota: The potential key target of TCM’s therapeutic effect of treating different diseases using the same method-UC and T2DM as examples. Frontiers in Cellular and Infection Microbiology, 12, 855075. https://doi.org/10.3389/fcimb.2022.855075

Zhang, X., Chen, Y., & Wang, L. (2016). Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway. BMC Complementary and Alternative Medicine, 16(1), 348. https://doi.org/10.1186/s12906-016-1273-z

Published

2025-06-14

Issue

Section

Review Article

How to Cite

The anti-inflammatory effect of turmeric on inflammatory bowel diseases. Research, Society and Development, [S. l.], v. 14, n. 6, p. e4414648985, 2025. DOI: 10.33448/rsd-v14i6.48985. Disponível em: https://ojs34.rsdjournal.org/index.php/rsd/article/view/48985. Acesso em: 29 jun. 2025.