Incidental finding of mixed hemoglobinopathy in pregnant woman - Case report
DOI:
https://doi.org/10.33448/rsd-v14i1.47956Keywords:
Beta thalassemia, Hemoglobin S, Hemoglobinopathies, Electrophoresis, Pregnant woman.Abstract
Microcytic and hypochromic anemic syndromes, beta-thalassemia type are usually underdiagnosed. Due to the similarity of clinical manifestations, the need for complementary studies, and the lack of clinical suspicion. This hinders their timely intervention. This study aimed to show a clinical case of an incidental finding of mixed hemoglobinopathy in a pregnant woman. we present the case of a 25-year-old primigravida patient hospitalized in the context of sepsis of urinary origin, associated with encapsulated bacteria. The hemogram reports low hemoglobin and refractoriness to iron treatment. Ferrokinetic studies were normal, the blood smear revealed a varied poikilocytosis, it was suggested to perform hemoglobin electrophoresis, which reported a mixed hemoglobinopathy as an incidental finding.
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Bender, M. A., Hulihan, M., Dorley, M. C., Aguinaga, M. del P., Ojodu, J., & Yusuf, C. (2021). Newborn screening practices for beta-thalassemia in the United States. International Journal of Neonatal Screening, 7(4), 83. https://doi.org/10.3390/ijns7040083
Beta-thalassemia - MeSH - NCBI. (s/f). Nih.gov.
Carvajal-Alzate, M. (2019). Vista de Beta-Talasemia: Un mundo de complicaciones con nuevas alternativas de tratamiento. Edu.co. https://doi.org/10.30554/archmed.19.1.2732.2019.
Electrophoresis - MeSH - NCBI. (s/f). Nih.gov. https://www.ncbi.nlm.nih.gov/mesh/68004586
Gasparini, N. P., Agriello, E. E., Lorena Zanella, M. J., Iommi, M. P., Maradei, J., & Sandoval, M. J. (2016). Síndrome drepanocítico: Asociación de hemoglobina S Y β talasemia. Medicina, 76(6), 369–372. https://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802016000600009
Hemoglobin, sickle - MeSH - NCBI. (s/f). Nih.gov. https://www.ncbi.nlm.nih.gov/mesh/68006451
Hemoglobinopathies - MeSH - NCBI. (s/f). Nih.gov. https://www.ncbi.nlm.nih.gov/mesh/?term=Hemoglobinopathies
Kasparek, J., Burkhardt, T., Hoesli, I., & Amstad Bencaiova, G. (2021). Pregnancy outcomes in women with a hemoglobinopathy trait: a multicenter, retrospective study. Archives of Gynecology and Obstetrics, 304(5), 1197–1203. https://doi.org/10.1007/s00404-021-06058-y
Luk’yanenko, V., Droogh, M., & Overgaard, U. M. (2017). Thalassaemia and pregnancy. Ugeskrift for laeger, 179(12).
Moukalled, N. M., Bou Fakhredin, R., & Taher, A. T. (2022). Pregnancy and sickle cell disease: an overview of complications and suggested perinatal care. Expert Review of Hematology, 15(12), 1055–1061. https://doi.org/10.1080/17474086.2022.2151432
Patel, J. P., Parikh, R. N., & Thorat, R. (2024). Effect of hemoglobinopathy on maternal and fetal outcome: Single center study. Journal of SAFOG, 16(4), 402–405. https://doi.org/10.5005/jp-journals-10006-2452
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Editora UAB/NTE/UFSM.
Pregnant women - MeSH - NCBI. (s/f). Nih.gov. https://www.ncbi.nlm.nih.gov/mesh/68037841
Sahli, C. A., Bibi, A., Ouali, F., Fredj, S. H., Dakhlaoui, B., Othmani, R., Laouini, N., Jouini, L., Ouenniche, F., Siala, H., Touhami, I., Becher, M., Fattoum, S., Toumi, N. E. H., & Messaoud, T. (2013). Red cell indices: differentiation between β-thalassemia trait and iron deficiency anemia and application to sickle-cell disease and sickle-cell thalassemia. Clinical Chemistry and Laboratory Medicine, 51(11), 2115–2124. https://doi.org/10.1515/cclm-2013-0354
Saliba, A. N., & Taher, A. T. (2016). Morbidities in non‐transfusion‐dependent thalassemia. Annals of the New York Academy of Sciences, 1368(1), 82–94. https://doi.org/10.1111/nyas.13083
Toassi, R. F. C., & Petry, P. C. (2021). Metodologia científica aplicada à área da saúde. Editora da UFRGS.
Vafaei, H., Karimi, S., Akbarzadeh Jahromi, M., Asadi, N., & Kasraeian, M. (2022). The effect of mother’s β-thalassemia minor on placental histology and neonatal outcomes. The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 35(10), 1907–1914. https://doi.org/10.1080/14767058.2020.1774540
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Copyright (c) 2025 Diego Fernando Lopez Muñoz; Karol Vanessa Gutierrez-Bonilla; Juan Camilo Castaño-Ospina; Cristhian Camilo Velandia-Mosquera; Valentina Taborda-Ipus; Caterine Eliseth Montezuma-Sanchez; Juan Andrés Galeano-Ruiz
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